Identification of average molecular weight (AMW) as a useful chemical descriptor to discriminate liver injury-inducing drugs
نویسندگان
چکیده
منابع مشابه
Multi-scale similarity entropy as a complexity descriptor to discriminate healthy to distress foetus
This paper deals with the discrimination between suffering foetuses and normal foetuses by means of a multi-scale similarity entropy. Sample entropy and similarity entropy are evaluated in multi-scale analysis on foetal heart rate signals. Without multi-scale analysis, our results show that only the similarity entropy differentiate suffering foetuses to normal foetuses. Furthermore with the mul...
متن کاملConfusion surrounding liver enzyme-inducing drugs.
Use of contraception outside the terms of the product licence That it should take our experts 17 pages to explain the problem of prescribing outside the licences of contraceptives surely exposes a credibility gap between regulation and prescribing. It seems we are now expected to know the detail of every licence of every drug we use and to tell the patient when we are outside the licence. This ...
متن کاملFactors affecting drug-induced liver injury: antithyroid drugs as instances
Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications. The mechanism(s) of hepatic injury induced by antithyroid agents is not fully recognized yet. Furthermore, there are no specific tools for predicting the occurrence of hepatotoxic...
متن کاملA Novel Molecular Descriptor Derived from Weighted Line Graph
The Bertz indices, derived by counting the number of connecting edges of line graphs of a molecule were used in deriving the QSPR models for the physicochemical properties of alkanes. The inability of these indices to identify the hetero centre in a chemical compound restricted their applications to hydrocarbons only. In the present work, a novel molecular descriptor has been derived from the w...
متن کاملNasal delivery of high molecular weight drugs.
Nasal drug delivery may be used for either local or systemic effects. Low molecular weight drugs with are rapidly absorbed through nasal mucosa. The main reasons for this are the high permeability, fairly wide absorption area, porous and thin endothelial basement membrane of the nasal epithelium. Despite the many advantages of the nasal route, limitations such as the high molecular weight (HMW)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2021
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0253855